Granulocyte Macrophage Colony-Stimulating Factor-Specific Autoantibodies and Cerebral Nocardia With Pulmonary Alveolar Proteinosis

Open Forum Infect Dis. 2020 Dec 13;8(2):ofaa612. doi: 10.1093/ofid/ofaa612. eCollection 2021 Feb.


In this study, we report the history of a 40-year-old man with a primary cerebral abscess caused by Nocardia abscessus that led to the discovery of autoimmune pulmonary alveolar lipoproteinosis (anti-granulocyte-macrophage colony-stimulating factor [GM-CSF] autoantibodies). Anti-GM-CSF autoantibodies promote immunodeficiency and should be monitored to prevent opportunistic and disseminated infections and to diagnose asymptomatic pulmonary alveolar lipoproteinosis.

Keywords: Nocardia; Pulmonary alveolar proteinosis’ Anti-GM-CSF antibody.

Publication types

  • Case Reports