The IL-27 receptor regulates TIGIT on memory CD4+ T cells during sepsis

Kristen N Morrow; Zhe Liang; Ming Xue; Deena B Chihade; Yini Sun; Ching-Wen Chen; Craig M Coopersmith; Mandy L Ford

doi:10.1016/j.isci.2021.102093

The IL-27 receptor regulates TIGIT on memory CD4⁺ T cells during sepsis

iScience. 2021 Jan 27;24(2):102093. doi: 10.1016/j.isci.2021.102093. eCollection 2021 Feb 19.

Authors

Kristen N Morrow^{1

2}, Zhe Liang², Ming Xue^{2

3}, Deena B Chihade², Yini Sun^{2

4}, Ching-Wen Chen^{1

2}, Craig M Coopersmith^{2

5}, Mandy L Ford^{2

6}

Affiliations

¹ Immunology and Molecular Pathogenesis Program, Laney Graduate School, Emory University, Atlanta, GA 30324, USA.
² Department of Surgery, Emory University School of Medicine, Atlanta, GA 30324, USA.
³ Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
⁴ Department of Critical Care Medicine, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang 110000, China.
⁵ Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA 30324, USA.
⁶ Emory Transplant Center, Emory University School of Medicine, Atlanta, GA 30324, USA.

Abstract

Sepsis is a leading cause of morbidity and mortality associated with significant impairment in memory T cells. These changes include the upregulation of co-inhibitory markers, a decrease in functionality, and an increase in apoptosis. Due to recent studies describing IL-27 regulation of TIGIT and PD-1, we assessed whether IL-27 impacts these co-inhibitory molecules in sepsis. Based on these data, we hypothesized that IL-27 was responsible for T cell dysfunction during sepsis. Using the cecal ligation and puncture (CLP) sepsis model, we found that IL-27Rα was associated with the upregulation of TIGIT on memory CD4⁺ T cells following CLP. However, IL-27 was not associated with sepsis mortality.

Keywords: Immunology; Molecular Biology.

Abstract

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