How can the latent cytomegalovirus cause an increase in all-cause mortality? An answer based on the microcompetition model

Antivir Ther. 2020;25(7):349-351. doi: 10.3851/IMP3384.


Many studies showed the existence of a positive association between cytomegalovirus (CMV) seropositivity and all-cause mortality. In this paper, we use the microcompetition model to explain how the latent CMV sequesters the limiting GABP∙p300/CBP transcription complex, which causes abnormal cellular gene expression, a chronic disease and mortality. Since most people harbour the latent CMV, we urge further research on this topic.

MeSH terms

  • Cytomegalovirus Infections*
  • Cytomegalovirus* / genetics
  • Humans