Case Report: Endogenous Candida Endophthalmitis in Cornelia de Lange Syndrome: Atypical Stellate Neuroretinitis

Optom Vis Sci. 2021 Feb 1;98(2):104-108. doi: 10.1097/OPX.0000000000001639.

Abstract

Significance: This study aimed to highlight the association of stellate neuroretinitis occurring secondary to endogenous candidemia.

Purpose: We report an unusual presentation of endogenous Candida endophthalmitis as a stellate neuroretinitis in the setting of Cornelia de Lange syndrome.

Case report: A 34-month-old girl with severe Cornelia de Lange syndrome and a history of parenteral nutrition dependence requiring a chronic central venous catheter presented with bilateral endophthalmitis secondary to candidemia. In one eye, the endophthalmitis had the atypical presentation as a stellate neuroretinitis.

Conclusions: This case represents a unique association of stellate neuroretinitis secondary to Candida infection in a patient with Cornelia de Lange syndrome.

Publication types

  • Case Reports

MeSH terms

  • Administration, Ophthalmic
  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Bacteremia / diagnosis
  • Bacteremia / drug therapy
  • Bacteremia / microbiology
  • Candida albicans / isolation & purification*
  • Candidemia / diagnosis
  • Candidemia / drug therapy
  • Candidemia / microbiology*
  • Candidiasis / diagnosis
  • Candidiasis / drug therapy
  • Candidiasis / microbiology*
  • Child, Preschool
  • De Lange Syndrome / complications*
  • Endophthalmitis / diagnosis
  • Endophthalmitis / drug therapy
  • Endophthalmitis / microbiology*
  • Eye Infections, Fungal / diagnosis
  • Eye Infections, Fungal / drug therapy
  • Eye Infections, Fungal / microbiology*
  • Female
  • Humans
  • Intravitreal Injections
  • Klebsiella / isolation & purification
  • Klebsiella Infections / diagnosis
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology
  • Retinitis / diagnosis
  • Retinitis / drug therapy
  • Retinitis / microbiology*
  • Voriconazole / therapeutic use

Substances

  • Antifungal Agents
  • Amphotericin B
  • Voriconazole