Innate and Adaptive Immunity: ILC2 and Th2 Cells in Upper and Lower Airway Allergic Diseases

Glenis K Scadding; Guy W Scadding

doi:10.1016/j.jaip.2021.02.013

Innate and Adaptive Immunity: ILC2 and Th2 Cells in Upper and Lower Airway Allergic Diseases

J Allergy Clin Immunol Pract. 2021 May;9(5):1851-1857. doi: 10.1016/j.jaip.2021.02.013. Epub 2021 Feb 20.

Authors

Glenis K Scadding¹, Guy W Scadding²

Affiliations

¹ Royal National ENT Hospital, London, UK. Electronic address: g.scadding@ucl.ac.uk.
² Royal Brompton Hospital, London, UK.

PMID: 33618052
DOI: 10.1016/j.jaip.2021.02.013

Abstract

Advances in our understanding of the immune system, with the recent discovery of a parallel set of innate T lymphocytes, the innate lymphocytes (ILCs), have led to a reassessment of the pathogenesis of allergic and eosinophilic airway disorders, including allergic rhinitis (AR), asthma, and chronic rhinosinusitis with nasal polyps. We review current understanding of both elements of type-2 inflammatory responses and their relative influence in these common conditions and consider possible impacts of this on treatment selection.

Keywords: Adaptive/acquired immunity; Allergic rhinitis; Asthma; Chronic rhinosinusitis with nasal polyps; Eosinophils; ILC2; Innate immunity; Th2.

Publication types

Review

MeSH terms

Adaptive Immunity
Humans
Immunity, Innate
Lymphocytes
Sinusitis*
Th2 Cells*