"Pregnancy and Lactation Associated Osteoporosis"
- PMID: 33620518
- DOI: 10.1007/s00223-021-00815-6
"Pregnancy and Lactation Associated Osteoporosis"
Abstract
Pregnancy-associated osteoporosis (PAO) is a rare condition of skeletal fragility affecting women in pregnancy or the postpartum period. During normal pregnancy and lactation, substantial changes in calcium metabolism and skeletal physiology occur in order to meet the demands of the developing foetus. Whilst these adaptations are reversible and generally of no clinical consequence for the mother, a small number of women will develop osteoporosis and suffer fragility fractures. Vertebral fractures occur most commonly in PAO and are often multiple. Due to the rarity of PAO, systematic study to date has been limited. Aetiology is poorly understood, but traditional osteoporosis risk factors and genetic factors are likely to play a role. A small number of cases may be due to an underlying metabolic bone disorder or monogenic condition. Management of PAO is challenging, due both to a poor evidence base and the fact that spontaneous improvement in BMD is known to occur once pregnancy and lactation are complete. Bisphosphonates, denosumab and teriparatide have all been used in individual patients, but the data supporting their use are currently limited.
Keywords: Fractures; Lactation; Osteoporosis; Pregnancy.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
Similar articles
-
Effect of teriparatide on pregnancy and lactation-associated osteoporosis with multiple vertebral fractures.J Bone Miner Metab. 2012 Sep;30(5):596-601. doi: 10.1007/s00774-011-0334-0. Epub 2011 Nov 23. J Bone Miner Metab. 2012. PMID: 22105654
-
Osteoporosis presenting in pregnancy, puerperium, and lactation.Curr Opin Endocrinol Diabetes Obes. 2014 Dec;21(6):468-75. doi: 10.1097/MED.0000000000000102. Curr Opin Endocrinol Diabetes Obes. 2014. PMID: 25191853 Review.
-
Teriparatide and denosumab treatment for pregnancy and lactation-associated osteoporosis with multiple vertebral fractures: A case study.Taiwan J Obstet Gynecol. 2017 Dec;56(6):863-866. doi: 10.1016/j.tjog.2017.10.028. Taiwan J Obstet Gynecol. 2017. PMID: 29241936
-
Presentation and management of osteoporosis presenting in association with pregnancy or lactation.Osteoporos Int. 2015 Sep;26(9):2223-41. doi: 10.1007/s00198-015-3149-3. Epub 2015 May 5. Osteoporos Int. 2015. PMID: 25939309 Review.
-
Clinical characteristics and bisphosphonates treatment of rare pregnancy- and lactation-associated osteoporosis.Clin Rheumatol. 2018 Nov;37(11):3141-3150. doi: 10.1007/s10067-018-4185-0. Epub 2018 Jun 26. Clin Rheumatol. 2018. PMID: 29946989
Cited by
-
Rehabilitation of Pregnancy and Lactation-Associated Osteoporosis and Vertebral Fractures: A Case Report.HSS J. 2024 May;20(2):298-305. doi: 10.1177/15563316231167148. Epub 2023 May 18. HSS J. 2024. PMID: 39281988 No abstract available.
-
Urinary Silicon Excretion in Relation to Lactation and Bone Mineral Density - a Longitudinal Study Post-partum.Biol Trace Elem Res. 2024 Apr 24. doi: 10.1007/s12011-024-04175-8. Online ahead of print. Biol Trace Elem Res. 2024. PMID: 38656681
-
Pregnancy-associated osteoporosis following in vitro fertilization: A case report.Clin Case Rep. 2024 Mar 21;12(3):e8702. doi: 10.1002/ccr3.8702. eCollection 2024 Mar. Clin Case Rep. 2024. PMID: 38523825 Free PMC article.
-
Pregnancy and lactation-related osteoporosis in a 22-year-old-woman.Clin Case Rep. 2024 Feb 12;12(2):e8489. doi: 10.1002/ccr3.8489. eCollection 2024 Feb. Clin Case Rep. 2024. PMID: 38348147 Free PMC article.
-
Clinical Features, Incidence and Treatment Outcome in Pregnancy-Associated Osteoporosis: A Single-Centre Experience over Two Decades.Calcif Tissue Int. 2023 Dec;113(6):591-596. doi: 10.1007/s00223-023-01139-3. Epub 2023 Oct 11. Calcif Tissue Int. 2023. PMID: 37819437 Free PMC article.
References
-
- Kovacs CS, Ralston SH (2015) Presentation and management of osteoporosis presenting in association with pregnancy or lactation. Osteoporos Int 26:2223–2241. https://doi.org/10.1007/s00198-015-3149-3 - DOI
-
- Kalkwarf HJ (2006) Calcium in pregnancy and lactation. In: Weaver CM, Heaney RP (eds) Calcium in human health. Humana Press, Totowa, pp 297–309 - DOI
-
- Kovacs C, Kronenberg H (2013) Pregnancy and lactation. In: Rosen C (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism, 8th edn. Wiley-Blackwell, Ames, pp 156–164 - DOI
-
- Kovacs C (2016) Maternal mineral and bone metabolism during pregnancy, lactation, and post-weaning recovery. Physiol Rev 96:449–547. https://doi.org/10.1152/physrev.00027.2015 - DOI
-
- Purdie DW, Aaron JE, Selby PL (1988) Bone histology and mineral homeostasis in human pregnancy. BJOG 95:849–54. https://doi.org/10.1111/j.1471-0528.1988.tb06568.x - DOI
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
