CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice

Circ Res. 2021 Apr 30;128(9):1258-1275. doi: 10.1161/CIRCRESAHA.120.318688. Epub 2021 Feb 24.

Abstract

[Figure: see text].

Keywords: atherosclerosis; cell proliferation; cholesterol; inflammation; phenotype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atherosclerosis / etiology*
  • Atherosclerosis / pathology
  • Cell Dedifferentiation*
  • Cell Movement
  • Cell Proliferation
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Coronary Vessels / cytology
  • Down-Regulation
  • Gene Knockdown Techniques
  • Gene Silencing
  • Humans
  • Lipid Metabolism
  • Mice
  • MicroRNAs / metabolism*
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / physiology*
  • Oligonucleotides, Antisense
  • Phenotype
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism
  • RNA, Long Noncoding / physiology*
  • Transcriptome

Substances

  • MIRN143 microRNA, human
  • MIRN145 microRNA, human
  • MicroRNAs
  • Oligonucleotides, Antisense
  • RNA, Long Noncoding
  • long non-coding RNA CARMEN, human