A major inhibitor of phenytoin binding to serum protein in uremia

Nephron. 1988;48(4):310-4. doi: 10.1159/000184949.


A major endogenous ligand substance, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), accumulated in the sera of uremic patients, inhibited phenytoin binding to pooled serum obtained from healthy subjects and to human serum albumin in a concentration usually observed in the sera of patients with uremia. This suggests that CMPF is a major drug-binding inhibitor present in uremic serum and may be one of the so-called 'uremic toxins'.

MeSH terms

  • Adult
  • Binding, Competitive
  • Furans*
  • Humans
  • In Vitro Techniques
  • Male
  • Middle Aged
  • Phenytoin / blood*
  • Propionates / blood*
  • Protein Binding / drug effects
  • Serum Albumin / metabolism*
  • Uremia / blood*


  • Furans
  • Propionates
  • Serum Albumin
  • Phenytoin
  • 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid