Monomeric C-Reactive Protein - A Feature of Inflammatory Disease Associated With Cardiovascular Pathophysiological Complications?

Yasmin Zeinolabediny; Shant Kumar; Mark Slevin

doi:10.21873/invivo.12309

Monomeric C-Reactive Protein - A Feature of Inflammatory Disease Associated With Cardiovascular Pathophysiological Complications?

In Vivo. 2021 Mar-Apr;35(2):693-697. doi: 10.21873/invivo.12309.

Authors

Yasmin Zeinolabediny¹, Shant Kumar¹, Mark Slevin²

Affiliations

¹ Department of Life Sciences, Metropolitan University, Manchester, Manchester, U.K.
² Department of Life Sciences, Metropolitan University, Manchester, Manchester, U.K. m.a.slevin@mmu.ac.uk.

Abstract

Monomeric C-reactive protein (mCRP), the dissociated form of native C-reactive protein, is a critical molecule that causes and perpetuates inflammation in serious diseases. It has 'adhesive'-like properties causing aggregation of blood cells and platelets, and can stick permanently within arterial tissue where it can contribute to further complications including thrombosis, linking it potentially to atherosclerosis and subsequent acute coronary events. In this mini review, we discuss briefly the implications and the potential value of measuring and manipulating it for clinical diagnostics and therapeutic purposes.

Keywords: Cardiovascular; diagnostic; inflammation; monomeric c-reactive protein; review; therapeutic.

Publication types

Review

MeSH terms

Atherosclerosis* / complications
Blood Platelets
C-Reactive Protein
Humans
Inflammation
Thrombosis* / diagnosis
Thrombosis* / etiology

Substances

C-Reactive Protein