Acute kidney injury pathology and pathophysiology: a retrospective review

Clin Kidney J. 2020 Oct 10;14(2):526-536. doi: 10.1093/ckj/sfaa142. eCollection 2021 Feb.


Acute kidney injury (AKI) is the clinical term used for decline or loss of renal function. It is associated with chronic kidney disease (CKD) and high morbidity and mortality. However, not all causes of AKI lead to severe consequences and some are reversible. The underlying pathology can be a guide for treatment and assessment of prognosis. The Kidney Disease: Improving Global Outcomes guidelines recommend that the cause of AKI should be identified if possible. Renal biopsy can distinguish specific AKI entities and assist in patient management. This review aims to show the pathology of AKI, including glomerular and tubular diseases.

Keywords: AKI; acute tubular necrosis; hemoglobinuria; multiple myeloma; pathology; pathophysiology; review; rhabdomyolysis.

Publication types

  • Review