Seven Microaneurysms: Description of an Experimental Rodent Model for Neurovascular Training

Turk Neurosurg. 2021;31(2):217-222. doi: 10.5137/1019-5149.JTN.30673-20.1.


Aim: To demonstrate the microsurgical procedures, and to evaluate the feasibility of living models of experimental neurovascular training by developing new complex vascular exercises mimicking the most common intracranial aneurysms.

Material and methods: The procedures were performed under a Zeiss (OPMI pico f170) microscope using basic microsurgery instruments, 10/0 Nylon and blue Polypropylene micro-sutures. We selected adult albino Wistar rats weighing between 258 and 471g each. Seven different aneurysm types were created using carotid, jugular, cava, aorta and femoral vessels.

Results: Seven types of aneurysm were designed and created in the rat with a high-medium successful rate. There are differences in terms of realism and the difficulty of performance, according to the different types: lateral wall, bifurcation, top of the basilar, fusiform, fusiform + involved branch, Anterior Communicating Artery (ACoA) and giant. The steps and technical issues to produce these exercises are described.

Conclusion: We show the feasibility of creating several types of aneurysm using different vessels in a rodent model. Training on these models help to improve microsurgical skills, allowing safe practice for neurosurgeons in all stages of their career.

MeSH terms

  • Animals
  • Anterior Cerebral Artery / pathology
  • Anterior Cerebral Artery / surgery
  • Circle of Willis / pathology
  • Circle of Willis / surgery
  • Disease Models, Animal*
  • Female
  • Humans
  • Intracranial Aneurysm / pathology
  • Intracranial Aneurysm / surgery*
  • Microaneurysm / pathology
  • Microaneurysm / surgery*
  • Microsurgery / education*
  • Microsurgery / methods
  • Neurosurgical Procedures / education*
  • Neurosurgical Procedures / methods
  • Rats
  • Rats, Wistar
  • Rodentia
  • Vascular Surgical Procedures / education*
  • Vascular Surgical Procedures / methods