Physiology and pathology of eosinophils: Recent developments: Summary of the Focus Workshop Organized by DGAKI

Abstract

Over the last century, eosinophils have been regarded ambiguously either as 'friends' or 'foes'. Recent developments have greatly enhanced our understanding of the role and function of eosinophils in health and disease. Pathogenic eosinophilic inflammation can lead to severe diseases in various organs, such as the gastrointestinal tract, airways, heart and skin. In a 2-day focus workshop of the German Society for Allergology and Clinical Immunology (DGAKI), the state of the art was discussed and practical recommendations for diagnosis and treatment of eosinophilic diseases, with a particular focus on new biologics, such as anti-interleukin 5 and anti-interleukin 5R, were derived.

Keywords: DNAzyme against GATA3; eosinophil; anti-interleukin 5; eosinophil diseases; hypereosinophilic syndrome.