Knockout of the NONO Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1428-1445. doi: 10.1161/ATVBAHA.119.313581. Epub 2021 Feb 25.

Abstract

[Figure: see text].

Keywords: aorta; carrier proteins; coronary vessels; neointima; vascular system injuries.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carotid Artery Injuries / genetics
  • Carotid Artery Injuries / metabolism*
  • Carotid Artery Injuries / pathology
  • Carotid Artery, Common / metabolism
  • Carotid Artery, Common / pathology
  • Case-Control Studies
  • Cell Movement
  • Cell Proliferation
  • Coronary Artery Disease / genetics
  • Coronary Artery Disease / metabolism
  • Coronary Stenosis / genetics
  • Coronary Stenosis / metabolism
  • DNA-Binding Proteins / deficiency*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Disease Models, Animal
  • Extracellular Signal-Regulated MAP Kinases / metabolism
  • Gene Knockout Techniques
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle, Smooth, Vascular / metabolism*
  • Muscle, Smooth, Vascular / pathology
  • Myocytes, Smooth Muscle / metabolism*
  • Myocytes, Smooth Muscle / pathology
  • Neointima*
  • Phenotype
  • RAW 264.7 Cells
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Signal Transduction

Substances

  • DNA-Binding Proteins
  • NONO protein, human
  • Nono protein, mouse
  • RNA-Binding Proteins
  • Extracellular Signal-Regulated MAP Kinases