Decitabine may improve CAR-T efficacy in refractory/relapsed acute leukemia patients carrying TP53 alterations

Changju Qu; Yaohua Song; Jia Yin; Yunju Ma; Liqing Kang; Zheng Li; Haiping Dai; Xiaming Zhu; Lei Yu; Depei Wu; Xiaowen Tang

doi:10.1038/s41409-021-01230-z

Decitabine may improve CAR-T efficacy in refractory/relapsed acute leukemia patients carrying TP53 alterations

Bone Marrow Transplant. 2021 Jul;56(7):1710-1713. doi: 10.1038/s41409-021-01230-z. Epub 2021 Feb 24.

Authors

Changju Qu^#^{1

2}, Yaohua Song^#^{2

3}, Jia Yin^#^{1

2}, Yunju Ma^{1

2}, Liqing Kang^{4

5}, Zheng Li^{1

2}, Haiping Dai^{1

2}, Xiaming Zhu^{1

2}, Lei Yu^{4

5}, Depei Wu^{1

2}, Xiaowen Tang^{6

7}

Affiliations

¹ National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
² Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
³ Cyrus Tang Hematology Center, Soochow University, Suzhou, China.
⁴ School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.
⁵ Shanghai Unicar-Therapy Bio-medicine Technology Co., Ltd, Shanghai, China.
⁶ National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China. xwtang1020@163.com.
⁷ Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. xwtang1020@163.com.

^# Contributed equally.

PMID: 33627797
DOI: 10.1038/s41409-021-01230-z

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Azacitidine / therapeutic use
Decitabine / pharmacology
Decitabine / therapeutic use
Humans
Immunotherapy, Adoptive
Leukemia, Myeloid, Acute* / drug therapy
Leukemia, Myeloid, Acute* / genetics
Receptors, Chimeric Antigen*
Tumor Suppressor Protein p53 / genetics

Substances

Receptors, Chimeric Antigen
TP53 protein, human
Tumor Suppressor Protein p53
Decitabine
Azacitidine