Research on BOLD-fMRI Data Denoising Based on Bayesian Estimation and Adaptive Wavelet Threshold

Oxid Med Cell Longev. 2021 Feb 5;2021:8819384. doi: 10.1155/2021/8819384. eCollection 2021.


The acquisition of functional magnetic resonance imaging (fMRI) images of blood oxygen level-dependent (BOLD) effect and the signals to be analyzed is based on weak changes in the magnetic field caused by small changes in blood oxygen physiological levels, which are weak signals and complex in noise. In order to model and analyze the pathological and hemodynamic parameters of BOLD-fMRI images effectively, it is urgent to use effective signal analysis techniques to reduce the interference of noise and artifacts. In this paper, the noise characteristics of functional magnetic resonance imaging and the traditional signal denoising methods are analyzed. The Bayesian decision criterion takes into account the probability of the total occurrence of all kinds of references and the loss caused by misjudgment and has strong discriminability. So, an improved adaptive wavelet threshold denoising method based on Bayesian estimation is proposed. By using the correlation characteristics of multiscale wavelet coefficients, the corresponding wavelet components of useful signals and noises are processed differently; while retaining useful frequency information, the noise is weakened to the greatest extent. The new adaptive threshold wavelet denoising method based on Bayesian estimation is applied to the actual experiment, and the results of OEF (oxygen extraction fraction) are optimized. A series of simulation experiments are carried out to verify the effectiveness of the proposed method.

MeSH terms

  • Adult
  • Algorithms*
  • Bayes Theorem
  • Computer Simulation
  • Humans
  • Magnetic Resonance Imaging*
  • Oxygen / blood*
  • Signal-To-Noise Ratio
  • Wavelet Analysis*
  • Young Adult


  • Oxygen