The important role of TFEB in autophagy-lysosomal pathway and autophagy-related diseases: a systematic review

Eur Rev Med Pharmacol Sci. 2021 Feb;25(3):1641-1649. doi: 10.26355/eurrev_202102_24875.

Abstract

Autophagy is a main metabolic process in which eukaryotic cells use lysosomes to eliminate abnormal proteins and damaged organelles to maintain cell homeostasis. Studies have revealed that neurodegenerative diseases, tumor, hepatic diseases, etc. are related to abnormal autophagy processes in recent years. Recent studies have shown that TFEB is a major transcription regulator of autophagy-lysosomal pathway (ALP) transcriptional regulation, which positively regulates the expression of autophagy and lysosomal biogenesis-related genes, thereby promoting autophagosome formation, autophagosome-lysosome fusion, and degradation of autophagy substrates. It has also been found that TFEB promotes clearance of intracellular substrates through lysosomal exocytosis. Therefore, the study of biological functions and related regulatory mechanisms of TFEB will provide important clues and theoretical basis for further explaining its physiological pathogenesis and the treatment of related diseases.

Publication types

  • Systematic Review

MeSH terms

  • Animals
  • Autophagy*
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism*
  • Humans
  • Lysosomes / metabolism
  • Neoplasms / metabolism*
  • Neurodegenerative Diseases / metabolism*

Substances

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors