Anti-MOG antibodies associated demyelination following encephalomeningitis: Case report

J Neuroimmunol. 2021 Apr 15:353:577519. doi: 10.1016/j.jneuroim.2021.577519. Epub 2021 Feb 10.

Abstract

Myelin oligodendrocyte glycoprotein (MOG) antibodies have been found in a broad range of demyelination diseases. In the present study, we reported three cases of patients with anti-MOG antibodies associated disorders (MOG-ADs) who initially presented as intracranial infection like encephalomeningitis with no evidence of demyelination injury, but were subsequently found the expression of MOG antibodies and other demyelination presentations. Our findings suggested that MOG-ADs can start as an intracranial infection like prodromal symptoms prior to the lesions of optic nerve, spinal cord, and white matter. Therefore, clinicians should be cautious of MOG-ADs in cases of encephalomeningitis even without demyelination injury.

Keywords: Autoimmune disease; Case report; Encephalomeningitis; Intracranial infection; MOG antibody-associated disorders.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Autoantibodies / immunology
  • Autoantigens / immunology
  • Demyelinating Autoimmune Diseases, CNS / immunology*
  • Demyelinating Autoimmune Diseases, CNS / pathology*
  • Female
  • Humans
  • Male
  • Meningoencephalitis / immunology*
  • Meningoencephalitis / pathology
  • Myelin-Oligodendrocyte Glycoprotein / immunology*
  • Young Adult

Substances

  • Autoantibodies
  • Autoantigens
  • MOG protein, human
  • Myelin-Oligodendrocyte Glycoprotein