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Observational Study
. 2021 Mar;42(3):255-263.
doi: 10.15537/smj.2021.42.3.20200695.

Does the fibrinogen/albumin ratio predict the prognosis of pregnancies with abortus imminens?

Ceyda S Usta  1 , Tugba K Atik  1 , Ruhsen Ozcaglayan  1 , Cagla B Bulbul  1 , Figen E Camili  1 , Ertan Adali  1
Affiliations
Free PMC article
Observational Study

Does the fibrinogen/albumin ratio predict the prognosis of pregnancies with abortus imminens?

Ceyda S Usta et al. Saudi Med J. 2021 Mar.
Free PMC article

Abstract

Objectives: To investigate the fibrinogen/albumin ratio (FAR) of pregnant women with abortus imminens (AI) and its prognostic value for predicting spontaneous abortion.

Methods: A total 102 early pregnancies, 52 had been diagnosed with AI and 50 ages and body mass index matched healthy control pregnant women were included in this prospective observational study conducted in the Research and Training Hospital, Balikesir University, Balikesir, Turkey between September 2019 and August 2020. Fibrinogen/albumin values were compared between AI and control group.

Results: The rate of spontaneous abortion in AI pregnancies was 26.9% in our study population. Fibrinogen/albumin ratio levels were higher in AI pregnancies than in controls (p=0.0088). The regression analysis have shown that the increased FAR value (odds ratio [OR]: 7.3116 [95% CI: 1.3119 to 40.7507]; p=0.0232) was an independent marker for spontaneous abortion prediction in AI pregnancies.

Conclusion: Pregnancies with AI have increased levels of FAR compared to healthy pregnancies. Fibrinogen/albumin ratio is an independent marker for predicting spontaneous abortion.

Keywords: abortus imminens; fibrinogen to albumin ratio; inflammation; spontaneous abortion.

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Figures

Figure 1
Figure 1
- The receiver operating characteristic analysis was performed to investigate the effect of FAR value in predicting spontaneous abortion in pregnancies with abortus imminens; FAR: Fibrinogen to albumin ratio. The area under the ROC curve of FAR was 0.803 (p<0.001).
Figure 2
Figure 2
- Plasma levels of fibrinogen in the groups (data show a mean±SD). Subgroup analysis demonstrated that plasma fibrinogen concentration was significantly higher in abortus imminens (AI) with spontaneous abortion (SA) than AI without SA and controls (p=0.001, ANOVA test).
Figure 3
Figure 3
- Plasma levels of fibrinogen in the groups (data show a mean±SD). Subgroup analysis demonstrated that plasma fibrinogen concentration was significantly higher in abortus imminens (AI) with spontaneous abortion (SA) than AI without SA and controls (p=0.001, ANOVA test).
Figure 4
Figure 4
- Fibrinogen/albumin ratio (FAR) in the groups (Data show a mean±SD). Subgroup analysis demonstrated that FAR levels were significantly higher in abortus imminens (AI) with spontaneous abortion (SA) than AI without SA and controls (p<0.001, ANOVA test)
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