Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies

Jun-Fang Zhang; Xi-Xi Wang; Ya Feng; Robert Fekete; Joseph Jankovic; Yun-Cheng Wu

doi:10.3389/fpsyt.2021.635494

Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies

Front Psychiatry. 2021 Feb 9:12:635494. doi: 10.3389/fpsyt.2021.635494. eCollection 2021.

Authors

Jun-Fang Zhang¹, Xi-Xi Wang^{1

2}, Ya Feng¹, Robert Fekete³, Joseph Jankovic⁴, Yun-Cheng Wu¹

Affiliations

¹ Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Shanghai General Hospital of Nanjing Medical University, Nanjing, China.
³ Department of Neurology, New York Medical College, New York, NY, United States.
⁴ Department of Neurology, Baylor College of Medicine, Houston, TX, United States.

Abstract

Impulse control disorders (ICDs) in Parkinson's disease (PD) are aberrant behavior such as pathological gambling, hypersexuality, binge eating, and compulsive buying, which typically occur as a result of dopaminergic therapy. Numerous studies have focused on the broad spectrum of ICDs-related behaviors and their tremendous impact on patients and their family members. Recent advances have improved our understanding of ICDs. In this review, we discuss the epidemiology, pathogenesis and treatment of ICDs in the setting of PD.

Keywords: Parkinson's disease; binge eating; compulsive buying; dopaminergic drugs; hypersexuality; impulse control disorders; pathological gambling.

Publication types

Review