BDNF serum concentrations in 2053 participants of the Berlin Aging Study II

Neurobiol Aging. 2021 May;101:221-223. doi: 10.1016/j.neurobiolaging.2021.01.020. Epub 2021 Feb 2.

Abstract

Serum BDNF concentrations in 2053 participants of the Berlin Aging Study II (BASE-II; 1572 individuals from the older age group [60-85 years], 481 individuals from the younger-age reference group [22-37 years]) were studied. There was no effect of age, sex, body mass index, self-reported depression, or BDNF Val66Met variant on serum BDNF concentrations. Multiple linear regression analysis failed to detect significant relationships of Digit Symbol Substitution Test score and Consortium to Establish a Registry for Alzheimer's Disease memory score to BDNF levels. However, we detected a positive correlation between platelet counts and BDNF levels (r = 0.303, p < 0.001). Our findings do not support an effect of aging, self-reported depression, or the Val66Met variant on serum BDNF concentrations. The role of thrombocytes in the biology of serum BDNF merits further study.

Keywords: Aging; Brain-derived neurotrophic factor; Depression; Platelet.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / blood*
  • Alzheimer Disease / diagnosis*
  • Berlin
  • Biomarkers / blood
  • Blood Platelets / metabolism
  • Brain-Derived Neurotrophic Factor / blood*
  • Brain-Derived Neurotrophic Factor / genetics
  • Female
  • Genetic Variation
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Platelet Count

Substances

  • Biomarkers
  • Brain-Derived Neurotrophic Factor