Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Natalie Lorenz; Timothy K C Ho; Reuben McGregor; Mark R Davies; Deborah A Williamson; Jason K Gurney; Pierre R Smeesters; Michael G Baker; Nicole J Moreland

doi:10.1093/cid/ciab180

Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Clin Infect Dis. 2021 Dec 16;73(12):2322-2325. doi: 10.1093/cid/ciab180.

Authors

Natalie Lorenz^{1

2}, Timothy K C Ho¹, Reuben McGregor^{1

2}, Mark R Davies³, Deborah A Williamson³, Jason K Gurney⁴, Pierre R Smeesters⁵, Michael G Baker^{2

4}, Nicole J Moreland^{1

2}

Affiliations

¹ School of Medical Sciences, University of Auckland, Auckland, New Zealand.
² Maurice Wilkins Centre for Biodiscovery, Auckland, New Zealand.
³ Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.
⁴ Department of Public Health, University of Otago, Wellington, New Zealand.
⁵ Molecular Bacteriology Laboratory, Université Libre de Bruxelles, Brussels, Belgium.

PMID: 33639619
DOI: 10.1093/cid/ciab180

Abstract

Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

Keywords: emm-cluster; emm-type; group A Streptococcus; immune priming; rheumatic fever.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Bacterial
Humans
Rheumatic Fever* / complications
Streptococcal Infections* / complications
Streptococcus pyogenes

Substances

Antigens, Bacterial

Abstract

Publication types

MeSH terms

Substances

Grants and funding