How to Test Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines Ethically Even After One Is Available

Clin Infect Dis. 2021 Dec 16;73(12):2332-2334. doi: 10.1093/cid/ciab182.


Although vaccines against severe acute respiratory syndrome coronavirus 2 have now been found safe and efficacious, there remains an urgent global health need to test both these vaccines and additional vaccines against the same virus. Under variable conditions, either standard or unusual designs would for both familiar and often-missed reasons make continued testing possible and ethical.

Keywords: COVID-19 vaccine; ethics; randomized controlled trials as topic.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19*
  • Humans
  • Morals
  • SARS-CoV-2
  • Vaccines*


  • Vaccines