Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children

doi:10.1016/j.jpeds.2021.02.062

Case Reports

. 2021 Jun:233:263-267.

doi: 10.1016/j.jpeds.2021.02.062. Epub 2021 Feb 26.

Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children

Andrew E Becker¹, Kathleen Chiotos², Jennifer L McGuire³, Benjamin B Bruins⁴, Alicia M Alcamo⁵

Affiliations

¹ Division of Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
² Division of Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; Division of Infectious Disease, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Anesthesiology and Critical Care Medicine, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
³ Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Neurology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
⁴ Division of Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Anesthesiology and Critical Care Medicine, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Division of General Anesthesia, The Children's Hospital of Philadelphia, Philadelphia, PA.
⁵ Division of Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Anesthesiology and Critical Care Medicine, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

PMID: 33640331
PMCID: PMC7906854
DOI: 10.1016/j.jpeds.2021.02.062

Case Reports

Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children

Andrew E Becker et al. J Pediatr. 2021 Jun.

. 2021 Jun:233:263-267.

doi: 10.1016/j.jpeds.2021.02.062. Epub 2021 Feb 26.

Authors

Andrew E Becker¹, Kathleen Chiotos², Jennifer L McGuire³, Benjamin B Bruins⁴, Alicia M Alcamo⁵

Affiliations

¹ Division of Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
² Division of Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; Division of Infectious Disease, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Anesthesiology and Critical Care Medicine, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
³ Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Neurology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
⁴ Division of Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Anesthesiology and Critical Care Medicine, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Division of General Anesthesia, The Children's Hospital of Philadelphia, Philadelphia, PA.
⁵ Division of Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Anesthesiology and Critical Care Medicine, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

PMID: 33640331
PMCID: PMC7906854
DOI: 10.1016/j.jpeds.2021.02.062

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is characterized by fever and multiorgan system dysfunction. Neurologic complications of MIS-C are not well described. We present 4 patients with MIS-C who had intracranial hypertension and discuss the unique management considerations when this occurs concurrently with significant myocardial dysfunction.

Keywords: COVID-19; PIM-TS; PIMS; SARS-CoV-2; coronavirus disease 2019; increased intracranial pressure; myocardial dysfunction; neurologic dysfunction; pediatric; pediatric critical care.

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References

1. CDC . Centers for Disease Control and Prevention; 2020. Multisystem Inflammatory Syndrome in Children (MIS-C) [Internet]www.cdc.gov/mis-c/hcp/ Accessed October 24, 2020.
1. Ahmed M., Advani S., Moreira A., Zoretic S., Martinez J., Chorath K., et al. Multisystem inflammatory syndrome in children: a systematic review. EClinicalMedicine. 2020;26:100527. - PMC - PubMed
1. Verdoni L., Mazza A., Gervasoni A., Martelli L., Ruggeri M., Ciuffreda M., et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020;395:1771–1778. - PMC - PubMed
1. Toubiana J., Poirault C., Corsia A., Bajolle F., Fourgeaud J., Angoulvant F., et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369:m2094. - PMC - PubMed
1. Dufort E.M., Koumans E.H., Chow E.J., Rosenthal E.M., Muse A., Rowlands J., et al. Multisystem inflammatory syndrome in children in New York State. N Engl J Med. 2020;383:347–358. - PMC - PubMed

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[1] CDC . Centers for Disease Control and Prevention; 2020. Multisystem Inflammatory Syndrome in Children (MIS-C) [Internet]www.cdc.gov/mis-c/hcp/ Accessed October 24, 2020.

[2] CDC . Centers for Disease Control and Prevention; 2020. Multisystem Inflammatory Syndrome in Children (MIS-C) [Internet]www.cdc.gov/mis-c/hcp/ Accessed October 24, 2020.

[3] Ahmed M., Advani S., Moreira A., Zoretic S., Martinez J., Chorath K., et al. Multisystem inflammatory syndrome in children: a systematic review. EClinicalMedicine. 2020;26:100527. - PMC - PubMed

[4] Ahmed M., Advani S., Moreira A., Zoretic S., Martinez J., Chorath K., et al. Multisystem inflammatory syndrome in children: a systematic review. EClinicalMedicine. 2020;26:100527. - PMC - PubMed

[5] Verdoni L., Mazza A., Gervasoni A., Martelli L., Ruggeri M., Ciuffreda M., et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020;395:1771–1778. - PMC - PubMed

[6] Verdoni L., Mazza A., Gervasoni A., Martelli L., Ruggeri M., Ciuffreda M., et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020;395:1771–1778. - PMC - PubMed

[7] Toubiana J., Poirault C., Corsia A., Bajolle F., Fourgeaud J., Angoulvant F., et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369:m2094. - PMC - PubMed

[8] Toubiana J., Poirault C., Corsia A., Bajolle F., Fourgeaud J., Angoulvant F., et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369:m2094. - PMC - PubMed

[9] Dufort E.M., Koumans E.H., Chow E.J., Rosenthal E.M., Muse A., Rowlands J., et al. Multisystem inflammatory syndrome in children in New York State. N Engl J Med. 2020;383:347–358. - PMC - PubMed

[10] Dufort E.M., Koumans E.H., Chow E.J., Rosenthal E.M., Muse A., Rowlands J., et al. Multisystem inflammatory syndrome in children in New York State. N Engl J Med. 2020;383:347–358. - PMC - PubMed

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Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children

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Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children

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