Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children

J Pediatr. 2021 Jun;233:263-267. doi: 10.1016/j.jpeds.2021.02.062. Epub 2021 Feb 26.


Multisystem inflammatory syndrome in children (MIS-C) is characterized by fever and multiorgan system dysfunction. Neurologic complications of MIS-C are not well described. We present 4 patients with MIS-C who had intracranial hypertension and discuss the unique management considerations when this occurs concurrently with significant myocardial dysfunction.

Keywords: COVID-19; PIM-TS; PIMS; SARS-CoV-2; coronavirus disease 2019; increased intracranial pressure; myocardial dysfunction; neurologic dysfunction; pediatric; pediatric critical care.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • COVID-19 / complications*
  • COVID-19 / epidemiology
  • Child
  • Female
  • Humans
  • Intracranial Hypertension / etiology*
  • Intracranial Hypertension / physiopathology
  • Intracranial Pressure / physiology*
  • Male
  • Pandemics
  • SARS-CoV-2*
  • Systemic Inflammatory Response Syndrome / complications*
  • Systemic Inflammatory Response Syndrome / epidemiology

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related