Clinical Efficacy of Cefixime for the Treatment of Early Syphilis

doi:10.1093/cid/ciab187

Randomized Controlled Trial

. 2021 Sep 7;73(5):907-910.

doi: 10.1093/cid/ciab187.

Clinical Efficacy of Cefixime for the Treatment of Early Syphilis

Chrysovalantis Stafylis¹, Kori Keith², Shivani Mehta², David Tellalian³, Pamela Burian³, Carl Millner³, Jeffrey D Klausner¹

Affiliations

¹ Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
² Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
³ Department of Medicine, AIDS Healthcare Foundation, Los Angeles, California, USA.

PMID: 33640982
PMCID: PMC8423500
DOI: 10.1093/cid/ciab187

Randomized Controlled Trial

Clinical Efficacy of Cefixime for the Treatment of Early Syphilis

Chrysovalantis Stafylis et al. Clin Infect Dis. 2021.

. 2021 Sep 7;73(5):907-910.

doi: 10.1093/cid/ciab187.

Authors

Chrysovalantis Stafylis¹, Kori Keith², Shivani Mehta², David Tellalian³, Pamela Burian³, Carl Millner³, Jeffrey D Klausner¹

Affiliations

¹ Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
² Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
³ Department of Medicine, AIDS Healthcare Foundation, Los Angeles, California, USA.

PMID: 33640982
PMCID: PMC8423500
DOI: 10.1093/cid/ciab187

Abstract

Safe and efficacious alternative treatment options for syphilis are necessary. This randomized, 2-arm, noncomparative pilot study evaluated the efficacy of oral cefixime 400 mg in achieving a ≥4-fold rapid plasma reagin titer decrease by 3 or 6 months after treatment. The proportion of cefixime arm participants treated successfully was 87% (95% confidence interval, 69%-100%; 13/15). Clinical Trials Registration. NCT03752112.

Keywords: Treponema pallidum; cefixime; early syphilis; penicillin; syphilis.

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References

1. World Health Organization. WHO guidelines for the treatment of Treponema pallidum (syphilis). Geneva, Switzerland: WHO, 2016. - PubMed
1. Jarzebowski W, Caumes E, Dupin N, et al. ; FHDH-ANRS CO4 Study Team . Effect of early syphilis infection on plasma viral load and CD4 cell count in human immunodeficiency virus-infected men: results from the FHDH-ANRS CO4 cohort. Arch Intern Med 2012; 172:1237–43. - PubMed
1. Buchacz K, Patel P, Taylor M, et al. . Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections. AIDS 2004; 18:2075–9. - PMC - PubMed
1. Centers for Disease Control and Prevention. Syphilis Surveillance Supplement 2013-2017 Centers for Disease Control and Prevention. 2019. Available at: https://www.cdc.gov/nchhstp/atlas/.
1. Clement ME, Okeke NL, Hicks CB. Treatment of syphilis: a systematic review. JAMA 2014; 312:1905–17. - PMC - PubMed

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[1] World Health Organization. WHO guidelines for the treatment of Treponema pallidum (syphilis). Geneva, Switzerland: WHO, 2016. - PubMed

[2] World Health Organization. WHO guidelines for the treatment of Treponema pallidum (syphilis). Geneva, Switzerland: WHO, 2016. - PubMed

[3] Jarzebowski W, Caumes E, Dupin N, et al. ; FHDH-ANRS CO4 Study Team . Effect of early syphilis infection on plasma viral load and CD4 cell count in human immunodeficiency virus-infected men: results from the FHDH-ANRS CO4 cohort. Arch Intern Med 2012; 172:1237–43. - PubMed

[4] Jarzebowski W, Caumes E, Dupin N, et al. ; FHDH-ANRS CO4 Study Team . Effect of early syphilis infection on plasma viral load and CD4 cell count in human immunodeficiency virus-infected men: results from the FHDH-ANRS CO4 cohort. Arch Intern Med 2012; 172:1237–43. - PubMed

[5] Buchacz K, Patel P, Taylor M, et al. . Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections. AIDS 2004; 18:2075–9. - PMC - PubMed

[6] Buchacz K, Patel P, Taylor M, et al. . Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections. AIDS 2004; 18:2075–9. - PMC - PubMed

[7] Centers for Disease Control and Prevention. Syphilis Surveillance Supplement 2013-2017 Centers for Disease Control and Prevention. 2019. Available at: https://www.cdc.gov/nchhstp/atlas/.

[8] Centers for Disease Control and Prevention. Syphilis Surveillance Supplement 2013-2017 Centers for Disease Control and Prevention. 2019. Available at: https://www.cdc.gov/nchhstp/atlas/.

[9] Clement ME, Okeke NL, Hicks CB. Treatment of syphilis: a systematic review. JAMA 2014; 312:1905–17. - PMC - PubMed

[10] Clement ME, Okeke NL, Hicks CB. Treatment of syphilis: a systematic review. JAMA 2014; 312:1905–17. - PMC - PubMed

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Clinical Efficacy of Cefixime for the Treatment of Early Syphilis

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Clinical Efficacy of Cefixime for the Treatment of Early Syphilis

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