Treatment personalization in gastrointestinal neuroendocrine tumors

Curr Treat Options Oncol. 2021 Feb 27;22(4):29. doi: 10.1007/s11864-021-00825-4.


The clinical scenario of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) is continuously changing due to significant improvements in the definition of their molecular landscapes and the introduction of innovative therapeutic approaches. Many efforts are currently employed in the integration of the genetics/epigenetics and clinical information. This is leading to an improvement of tumor classification, prognostic stratification and ameliorating the management of patients based on a personalized approach.

Keywords: GEP-NENs; Immunotherapy; NETs; PRRT; SSAs; Targeted therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor
  • Clinical Decision-Making
  • Combined Modality Therapy
  • Diagnostic Imaging / methods
  • Disease Management
  • Disease Susceptibility
  • Gastrointestinal Neoplasms / diagnosis
  • Gastrointestinal Neoplasms / etiology
  • Gastrointestinal Neoplasms / mortality
  • Gastrointestinal Neoplasms / therapy*
  • Humans
  • Multimodal Imaging / methods
  • Neuroendocrine Tumors / diagnosis
  • Neuroendocrine Tumors / etiology
  • Neuroendocrine Tumors / mortality
  • Neuroendocrine Tumors / therapy*
  • Precision Medicine* / methods
  • Prognosis
  • Treatment Outcome


  • Biomarkers, Tumor