Long Noncoding RNAs: Potential Mediators of Liver Cancer Metastasis

Crit Rev Oncog. 2021;26(1):21-33. doi: 10.1615/CritRevOncog.2020035666.

Abstract

Liver cancer (LC) is the most common high-mortality malignancy, due to its aggressive nature, heterogeneity, and metastasis. Recent studies have recognized long noncoding RNAs (lncRNAs) as mediators of LC pathogenesis and metastasis. This review describes the role of lncRNAs in molecular mechanisms of tumorigenicity, metastasis, stem-cell maintenance, drug resistance, and tumor immunity. We present recent updates on therapeutic targeting of lncRNAs in LC as well as lncRNA's potential for LC diagnosis. Overall, we provide a new perspective on the role of lncRNAs for LC treatment and diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Liver Neoplasms* / genetics
  • RNA, Long Noncoding* / genetics

Substances

  • RNA, Long Noncoding