HOS15-PWR chromatin remodeling complex positively regulates cold stress in Arabidopsis

Plant Signal Behav. 2021 May 4;16(5):1893978. doi: 10.1080/15592324.2021.1893978. Epub 2021 Mar 1.

Abstract

Cold stress is a major environmental constraint that restrains plant growth and productivity. To cope with cold stress, plants must be able to perceive a cold signal and regulate the expression of cold-regulated (COR) genes. In our recent study, we showed that Arabidopsis HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 15 (HOS15) acts as a substrate receptor for CULLIN4-based ubiquitin E3 ligase complex to promote cold-induced histone deacetylase 2 C (HD2C) degradation that allows the activation of COR genes. Additionally, we found that POWERDRESS (PWR), a HOS15-interacting protein, is required for the association of HOS15 with COR gene chromatin and HD2C degradation. The HOS15/PWR complex interacts with and recruits CBF transcription factors to the promoters of COR genes. Collectively, our previous findings suggest that HOS15 and PWR function as positive regulators for the expression of COR genes, and promote cold tolerance. Accordingly, we herein discuss the role of PWR in cold tolerance.

Keywords: CBF; COR gene; Cold stress signaling; HD2C; HOS15; PWR; cold tolerance; epigenetic regulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / genetics
  • Arabidopsis / physiology*
  • Arabidopsis Proteins / metabolism*
  • Chromatin Assembly and Disassembly*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Cold-Shock Response*
  • Freezing
  • Gene Expression Regulation, Plant
  • Histone Deacetylases / metabolism
  • Models, Biological
  • Phenotype
  • Proteolysis
  • Transcription Factors / metabolism*

Substances

  • Arabidopsis Proteins
  • Chromosomal Proteins, Non-Histone
  • Hos15 protein, Arabidopsis
  • POWERDRESS protein, Arabidopsis
  • Transcription Factors
  • HD2C protein, Arabidopsis
  • Histone Deacetylases

Grants and funding

This paper was supported by Konkuk University Researcher Fund in 2020, Next Generation Bio-Green21 Program, Rural Development Administration (RDA), Republic of Korea (SSAC, PJ01318201 to D.-J.Y); the National Research Foundation of Korea (NRF) funded by the Korean Government (2019R1A2C2084096 to D.-J.Y) and Global Research Lab (2017K1A1A2013146 to D.-J.Y.).