Accelerated and Blast Phase Myeloproliferative Neoplasms

Tania Jain; Raajit K Rampal

doi:10.1016/j.hoc.2020.12.008

Accelerated and Blast Phase Myeloproliferative Neoplasms

Hematol Oncol Clin North Am. 2021 Apr;35(2):325-335. doi: 10.1016/j.hoc.2020.12.008. Epub 2021 Feb 3.

Authors

Tania Jain¹, Raajit K Rampal²

Affiliations

¹ Division of Hematological Malignancies and Stem Cell Transplantation, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21287, USA. Electronic address: tjain2@jhmi.edu.
² Leukemia Service, Department of Medicine, Memorial Sloan Kettering, 530 East 74th Street, New York, NY 10021, USA. Electronic address: https://twitter.com/RaajitRampal.

PMID: 33641872
DOI: 10.1016/j.hoc.2020.12.008

Abstract

Accelerated and blast phase myeloproliferative neoplasms are advanced stages of the disease with historically a poor prognosis and little improvement in outcomes thus far. The lack of responses to standard treatments likely results from the more aggressive biology reflected by the higher incidence of complex karyotype and high-risk somatic mutations, which are enriched at the time of transformation. Treatment options include induction chemotherapy (7 + 3) as that used on de novo acute myeloid leukemia or hypomethylating agent-based therapy, which has shown similar outcomes. Allogeneic stem cell transplantation remains the only potential for cure.

Keywords: Accelerated phase; Acute myeloid leukemia; Blast phase; Myeloproliferative neoplasm.

Publication types

Review

MeSH terms

Blast Crisis* / genetics
Blast Crisis* / therapy
Hematopoietic Stem Cell Transplantation*
Humans
Leukemia, Myeloid, Acute* / genetics
Leukemia, Myeloid, Acute* / therapy
Mutation
Myeloproliferative Disorders* / genetics
Myeloproliferative Disorders* / therapy