Smoking topography and nicotine blood levels

Addict Behav. 1988;13(1):91-5. doi: 10.1016/0306-4603(88)90031-7.


Frequency and durational components of smoking topography were measured by a portable smoking device while 10 subjects smoked four cigarettes ad libitum in a non-laboratory environment. Nicotine blood levels were measured before and after smoking each cigarette and serial blood samples for determining nicotine metabolic half-life were obtained the following day. Results showed that change in pre- and post-cigarette nicotine levels and metabolic half-life for nicotine were not related to within-cigarette topography measures or nicotine yield of cigarette, but were significantly related to intercigarette interval.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Female
  • Half-Life
  • Humans
  • Male
  • Nicotine / pharmacokinetics*
  • Smoking / blood*
  • Smoking / psychology


  • Nicotine