Cyclosporine-A-Induced Intracranial Thrombotic Complications: Systematic Review and Cases Report

Si-Ying Song; Zhong-Ao Wang; Yu-Chuan Ding; Xun-Ming Ji; Ran Meng

doi:10.3389/fneur.2020.563037

Cyclosporine-A-Induced Intracranial Thrombotic Complications: Systematic Review and Cases Report

Front Neurol. 2021 Feb 11:11:563037. doi: 10.3389/fneur.2020.563037. eCollection 2020.

Authors

Si-Ying Song^{1

2

3}, Zhong-Ao Wang^{1

2

3}, Yu-Chuan Ding^{3

4}, Xun-Ming Ji^{1

2

3}, Ran Meng^{1

2

3}

Affiliations

¹ Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
² Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
³ Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
⁴ Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United States.

Abstract

This study reported two cases of intracranial thrombotic events of aplastic anemia (AA) under therapy with cyclosporine-A (CsA) and reviewed both drug-induced cerebral venous thrombosis (CVT) and CsA-related thrombotic events systematically. We searched PubMed Central (PMC) and EMBASE up to Sep 2019 for publications on drug-induced CVT and Cs-A-induced thrombotic events. Medical subject headings and Emtree headings were used with the following keywords: "cyclosporine-A" and "cerebral venous thrombosis OR cerebral vein thrombosis" and "stroke OR Brain Ischemia OR Brain Infarction OR cerebral infarction OR intracerebral hemorrhage OR intracranial hemorrhage." We found that CsA might be a significant risk factor in inducing not only CVT but also cerebral arterial thrombosis in patients with AA.

Keywords: case report; cerebral arterial infarction; cerebral venous sinus thrombosis; cyclosporine-A; systematic review.

Publication types

Case Reports