Keywords: BRAF inhibitors; DRESS, drug reaction with eosinophilia and systemic symptoms; MEK inhibitors; RESS syndrome; SCARs; checkpoint inhibitors; cobimetinib; dabrafenib; drug reaction with eosinophilia and systemic symptoms; encorafenib; malignant melanoma; metastatic melanoma; pembrolizumab; severe cutaneous adverse reactions; vemurafenib.