A COVID-19 pregnant patient with thrombotic thrombocytopenic purpura: a case report

J Med Case Rep. 2021 Mar 1;15(1):104. doi: 10.1186/s13256-020-02577-5.


Background: Pregnancy seems to increase the risk of thrombotic thrombocytopenic purpura (TTP) relapses and make the TTP more severe in any of the pregnancy trimesters, or even during the postpartum period.

Case presentation: This study highlights details of treating a COVID-19 pregnant patient who survived. This 21-year addicted White woman was admitted at her 29th week and delivered a stillbirth. She was transferred to another hospital after showing signs of TTP, which was caused by a viral infection.

Conclusion: This viral infection caused fever and dyspnea, and the patient was tested positive for COVID-19 infection. A chest computed tomography scan showed diffuse multiple bilateral consolidations and interlobar septal thickening. She stayed at the Intensive Care Unit for 20 days and treated with plasmapheresis. As far as we know, this is the first report of a TTP pregnant patient with COVID-19 infection.

Keywords: Addiction; COVID-19; Plasmapheresis; Pregnancy; Thrombotic thrombocytopenic purpura.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / therapy
  • Amphetamine-Related Disorders
  • Antiviral Agents / therapeutic use
  • COVID-19 / diagnosis*
  • COVID-19 / therapy
  • Drug Combinations
  • Erythrocyte Transfusion
  • Female
  • Hemoglobins / metabolism
  • Humans
  • Hydroxychloroquine / therapeutic use
  • Intensive Care Units
  • L-Lactate Dehydrogenase / metabolism
  • Lopinavir / therapeutic use
  • Methamphetamine
  • Plasmapheresis*
  • Pregnancy
  • Pregnancy Complications, Hematologic / diagnosis*
  • Pregnancy Complications, Hematologic / metabolism
  • Pregnancy Complications, Hematologic / therapy
  • Pregnancy Complications, Infectious / diagnosis*
  • Pregnancy Complications, Infectious / metabolism
  • Pregnancy Complications, Infectious / therapy
  • Purpura, Thrombotic Thrombocytopenic / diagnosis*
  • Purpura, Thrombotic Thrombocytopenic / metabolism
  • Purpura, Thrombotic Thrombocytopenic / therapy
  • Renal Dialysis
  • Ritonavir / therapeutic use
  • SARS-CoV-2
  • Stillbirth*
  • Tomography, X-Ray Computed
  • Young Adult


  • Antiviral Agents
  • Drug Combinations
  • Hemoglobins
  • lopinavir-ritonavir drug combination
  • Lopinavir
  • Methamphetamine
  • Hydroxychloroquine
  • L-Lactate Dehydrogenase
  • Ritonavir