18F-Fluciclovine PET for Assessment of Prostate Cancer with Histopathology as Reference Standard: A Systematic Review

Therese Seierstad; Knut Håkon Hole; Andreas Julius Tulipan; Hilde Strømme; Wolfgang Lilleby; Mona-Elisabeth Revheim; Eivor Hernes

doi:10.1016/j.cpet.2020.12.012

¹⁸F-Fluciclovine PET for Assessment of Prostate Cancer with Histopathology as Reference Standard: A Systematic Review

PET Clin. 2021 Apr;16(2):167-176. doi: 10.1016/j.cpet.2020.12.012.

Authors

Therese Seierstad¹, Knut Håkon Hole², Andreas Julius Tulipan², Hilde Strømme³, Wolfgang Lilleby⁴, Mona-Elisabeth Revheim², Eivor Hernes⁵

Affiliations

¹ Division of Radiology and Nuclear Medicine, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424 Oslo, Norway. Electronic address: therese@radium.uio.no.
² Division of Radiology and Nuclear Medicine, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424 Oslo, Norway; Institute of Clinical Medicine, University of Oslo, P.O. Box 1171 Blindern, 0318 Oslo, Norway.
³ Library of Medicine and Science, University of Oslo, Sognsvannsveien 20, 0372 Oslo, Norway.
⁴ Department of Oncology, Oslo University Hospital, P.O. Box 4953 Nydalen, 0424 Oslo, Norway.
⁵ Division of Radiology and Nuclear Medicine, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424 Oslo, Norway.

PMID: 33648662
DOI: 10.1016/j.cpet.2020.12.012

Abstract

The PET tracer ¹⁸F-fluciclovine (Axumin) was recently approved in the United States and Europe for men with suspected prostate cancer recurrence following prior treatment. This article summarizes studies where systematic sector-based histopathology was used as reference standard to assess the diagnostic accuracy of the tracer ¹⁸F-fluciclovine PET in patients with prostate cancer.

Keywords: Fluciclovine PET; Histopathology; PET/CT; PET/MR imaging; PSMA; Personalized medicine; Prostate cancer.

Publication types

Review
Systematic Review

MeSH terms

Carboxylic Acids
Cyclobutanes*
Humans
Male
Neoplasm Recurrence, Local
Positron Emission Tomography Computed Tomography
Prostatic Neoplasms* / diagnostic imaging
Reference Standards

Substances

Carboxylic Acids
Cyclobutanes
fluciclovine F-18