Fertility preservation in patients with BRCA mutations or Lynch syndrome

Int J Gynecol Cancer. 2021 Mar;31(3):332-338. doi: 10.1136/ijgc-2020-002071.

Abstract

Guidelines and expert consensus are lacking on fertility preservation in BRCA mutation carriers and in patients with Lynch syndrome. The safety of fertility preservation in this setting is still a topic of debate and multiple factors need to be carefully considered. The aim of this review was to analyze the reproductive potential of women harboring a genetic mutation affecting the DNA repair system and explore the efficacy and safety of existing fertility preservation strategies in these patients.

Keywords: BRCA1 protein; BRCA2 protein; lynch syndrome II.

Publication types

  • Review

MeSH terms

  • BRCA1 Protein*
  • BRCA2 Protein*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / prevention & control
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • Colorectal Neoplasms, Hereditary Nonpolyposis / prevention & control
  • Cryopreservation
  • Female
  • Fertility Preservation / methods*
  • Fertility Preservation / standards
  • Humans
  • Mutation
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / prevention & control
  • Ovarian Reserve / genetics
  • Pregnancy

Substances

  • BRCA1 Protein
  • BRCA2 Protein