The mechanism and prevention of mitochondrial injury after exercise

J Physiol Biochem. 2021 May;77(2):215-225. doi: 10.1007/s13105-021-00802-3. Epub 2021 Mar 2.

Abstract

With the development of society, physical activity has come to be an effective means by which people pursue good health to improve the quality of life. However, with the increase of intensity and the passage of time, exercise injury has become a hazard that can no longer be ignored. It is imperative to find effective ways to inhibit or reduce the negative effects of exercise. Mitochondria are important organelles involved in exercise and play an important role in exercise injury and prevention. Studies have found that exercise preconditioning and increased mitochondrial nutrition can effectively decrease mitochondrial damage after exercise. Against this background, some of the newest developments in this important field are reviewed here. The results discussed indicate that exercise preconditioning and supplement mitochondrial nutrition need to be increased to prevent exercise-related injuries.

Keywords: Exercise; Mitochondrial apoptosis; Mitochondrial injury.

Publication types

  • Review

MeSH terms

  • Apoptosis / drug effects
  • Athletic Injuries / metabolism
  • Athletic Injuries / prevention & control*
  • Calcium / metabolism
  • DNA Damage
  • Dietary Supplements*
  • Exercise*
  • Fatigue / metabolism
  • Fatigue / prevention & control*
  • Free Radicals / antagonists & inhibitors
  • Free Radicals / metabolism
  • Humans
  • Lipid Peroxidation / drug effects
  • Mitochondria / drug effects
  • Mitochondria / metabolism*
  • Mitochondria / pathology
  • Nitric Oxide / metabolism
  • Phenylethyl Alcohol / administration & dosage
  • Phenylethyl Alcohol / analogs & derivatives
  • Resveratrol / administration & dosage
  • Thioctic Acid / administration & dosage
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives

Substances

  • Free Radicals
  • 3,4-dihydroxyphenylethanol
  • Ubiquinone
  • Nitric Oxide
  • Thioctic Acid
  • coenzyme Q10
  • Phenylethyl Alcohol
  • Resveratrol
  • Calcium