The efficacy of oral vs different dilutions of intradermal tranexamic acid microinjections in melasma-A randomized clinical trial

Dermatol Ther. 2021 May;34(3):e14924. doi: 10.1111/dth.14924. Epub 2021 Mar 7.


Melasma is a common acquired disorder of pigmentation, remains challenging despite numerous treatment modalities. Tranexamic acid (TXA) has emerged as a potential treatment for melasma. Different forms of TXA (oral, topical, and intradermal microinjections) have shown promising results. To evaluate and compare the efficacy of oral vs different dilutions of intradermal TXA in melasma. A total of 45 female patients with melasma were randomly and equally assigned to three treatment groups. Group A (oral TXA 250 mg bid), Group B (100 mg/mL intradermal TXA) & Group C (4 mg/mL intradermal TXA) every 2 weeks, treatment period was 8 weeks. At 8 weeks, a significant reduction in the mMASIwas noted in groups A, B, and C (P value .002, .003, and .005). Melanin index (MI) was significantly reduced in groups A, B, and C (P value .016, .005, and .003). Erythema index (EI) showed significant improvement in group A (P value .028), however was statistically insignificant for groups B and C. No statistically significant difference was found between the three groups as regards changes in mMASI, MI, and EI at 8 weeks. Both oral and intradermal microinjections of TXA regardless dilution appear to be effective and safe in treatment of melasma with comparable results.

Keywords: Melasma; intradermal; microinjections; oral; tranexamic acid; treatment.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Cutaneous
  • Erythema / drug therapy
  • Female
  • Humans
  • Melanosis* / diagnosis
  • Melanosis* / drug therapy
  • Microinjections
  • Tranexamic Acid* / adverse effects
  • Treatment Outcome


  • Tranexamic Acid