Achieving metal-organic frameworks (MOFs) in the form of nanoparticles (NanoMOFs) represents a recent challenge due to the possibility to combine the intrinsic porosity of these materials with the nanometric dimension, a fundamental requirement for strategic biomedical applications. In this outlook we envision the current/future opportunities of the NanoMOFs in the field of biomedicine, with particular emphasis on (i) biocompatible MOFs composition; (ii) MOFs miniaturization and (iii) nanoMOFs applications.