At the Heart of Immune Checkpoint Inhibitor-Induced Immune Toxicity

Cancer Discov. 2021 Mar;11(3):537-539. doi: 10.1158/2159-8290.CD-21-0091.

Abstract

Wei and colleagues showcase a genetic mouse model of immune-mediated myocarditis that shares homology with immune checkpoint inhibitor (CPI)-induced myocarditis in patients with cancer. They demonstrate that abatacept (CTLA4-Ig) limits cardiac toxicity in the mouse model and, thus, may ameliorate the CPI-induced myocarditis in patients with cancer while potentially maintaining antitumor activity.See related article by Wei et al., p. 614.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Immune Checkpoint Inhibitors
  • Mice
  • Myocarditis* / chemically induced
  • Myocarditis* / drug therapy
  • Neoplasms* / drug therapy

Substances

  • Immune Checkpoint Inhibitors