Gorham-Stout Disease Resulting in Spinal Deformity Treated by Fusion Surgery Combined With Everolimus Therapy: A Case Report

JBJS Case Connect. 2021 Mar 3;11(1). doi: 10.2106/JBJS.CC.20.00296.

Abstract

Case: Gorham-Stout disease (GSD) is a rare disorder characterized by progressive localized osteolysis and lymphatic malformation. A 26-year-old woman with GSD presented to our hospital with a Cobb angle of 100° and a kyphosis angle of 88°. Everolimus therapy was initiated to control the disease prior to surgery. After halo-gravity traction for 4 weeks, we performed anterior and posterior spinal fusion. Postoperative computed tomography revealed satisfactory bone union and no significant loss of correction 1 year post-surgery.

Conclusion: This case suggests that anterior and posterior spinal fusion combined with everolimus therapy can be a therapeutic option for GSD.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Everolimus / therapeutic use
  • Female
  • Humans
  • Kyphosis* / diagnostic imaging
  • Kyphosis* / etiology
  • Kyphosis* / surgery
  • Osteolysis, Essential* / diagnostic imaging
  • Osteolysis, Essential* / drug therapy
  • Osteolysis, Essential* / surgery
  • Spinal Fusion* / methods
  • Traction

Substances

  • Everolimus