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Comment
. 2021 Apr 1;384(13):1273-1277.
doi: 10.1056/NEJMc2102131. Epub 2021 Mar 3.

Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2

Kimberly G Blumenthal  1 , Esther E Freeman  1 , Rebecca R Saff  1 , Lacey B Robinson  1 , Anna R Wolfson  1 , Ruth K Foreman  1 , Dean Hashimoto  2 , Aleena Banerji  3 , Lily Li  4 , Sara Anvari  5 , Erica S Shenoy  3
Affiliations
Comment

Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2

Kimberly G Blumenthal et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Delayed Cutaneous Reactions to mRNA-1273 Vaccine.
Shown are morphologic characteristics of delayed cutaneous reactions to mRNA-1273 vaccine, including annular plaques (in Patient 1), uniformly edematous plaques (in Patients 2, 6, and 11), and targetoid plaques (in Patient 3) near the site of vaccination. In several patients, there was considerable induration of the plaques (e.g., in Patients 8 and 9). In addition to a localized rash on the arm, two patients had other cutaneous symptoms, including papules on the palm and fingers (Patient 5) and urticarial plaques on the elbows (Patient 6). Patients 1, 5, 8, 9, 11, and 12 did not have a recurrence of large local reactions with the second dose, although some patients had minimal erythema. In Patients 2, 6, and 7, the reactions had an earlier onset and were lower grade after the second dose than after the first dose. In Patients 3, 4, and 10, the onset of the reactions after the second dose was earlier than after the first dose, but the reactions to the two doses were of a similar grade. Some photographs were taken by the patients using a mirror, so the images of the left and right arms may be transposed.
See this image and copyright information in PMC

Comment in

Comment on

  • Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
    Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, Diemert D, Spector SA, Rouphael N, Creech CB, McGettigan J, Khetan S, Segall N, Solis J, Brosz A, Fierro C, Schwartz H, Neuzil K, Corey L, Gilbert P, Janes H, Follmann D, Marovich M, Mascola J, Polakowski L, Ledgerwood J, Graham BS, Bennett H, Pajon R, Knightly C, Leav B, Deng W, Zhou H, Han S, Ivarsson M, Miller J, Zaks T; COVE Study Group. Baden LR, et al. N Engl J Med. 2021 Feb 4;384(5):403-416. doi: 10.1056/NEJMoa2035389. Epub 2020 Dec 30. N Engl J Med. 2021. PMID: 33378609 Free PMC article. Clinical Trial.

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References

    1. Baden LR, El Sahly HM, Essink B, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med 2021;384:403-416. - PMC - PubMed
    1. Kelso JM, Greenhawt MJ, Li JT, et al. Adverse reactions to vaccines practice parameter 2012 update. J Allergy Clin Immunol 2012;130:25-43. - PubMed