Drosophila Adh: a promoter element expands the tissue specificity of an enhancer

Cell. 1988 May 6;53(3):451-61. doi: 10.1016/0092-8674(88)90165-1.


Drosophila alcohol dehydrogenase (Adh) genes are expressed in the fat body and in species-specific sets of other tissues during larval and adult development. The Drosophila mulleri Adh-1 gene is expressed in the larval fat body and in three other larval tissues. In this paper, we show that Adh-1 expression in multiple cell types is the result of synergistic interactions between fat body-specific enhancers and a specific Adh-1 promoter element.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohol Dehydrogenase / analysis
  • Alcohol Dehydrogenase / genetics*
  • Animals
  • Chromosome Deletion
  • Drosophila / enzymology
  • Drosophila / genetics*
  • Enhancer Elements, Genetic*
  • Fat Body / enzymology
  • Larva / enzymology
  • Malpighian Tubules / enzymology
  • Mutation
  • Organ Specificity
  • Promoter Regions, Genetic*
  • Regulatory Sequences, Nucleic Acid
  • Species Specificity
  • Transcription, Genetic
  • Transformation, Genetic


  • Alcohol Dehydrogenase