Does Vitamin D affects changes in volumetric bone mineral density and architecture in postmenopausal women after conservatively treated distal radius fractures?

J Musculoskelet Neuronal Interact. 2021 Mar 1;21(1):93-103.


Objective: We examined the role of vitamin D on volumetric bone mineral density (vBMD) and architecture during the first week's post-fracture in postmenopausal women (PMW) with distal radial fractures (DRF) treated conservatively using peripheral Quantitative Computed Tomography (pQCT).

Methods: Patients were classified into 2 groups according to initial median 25(OH)D level; Group A (25(OH)D ≥15 ng/ml) and group B (25(OH)D <15 ng/ml). All patients were followed for 12 weeks at three visits: baseline, 6 weeks and 12 weeks post fracture. pQCT was performed at baseline in fractured and contralateral non-fractured radius and at 6th and 12th week on the fractured side.

Results: 39 patients completed the protocol. Mean 25(OH)D levels were 15.60±7.35 ng/ml (3.5-41.7). Trabecular (trab) bone mineral content (BMC) and trabvBMD increased at 6 wk. vs. baseline (p<0.001). Cortical BMC, cortvBMD and cross- sectional area (CSA) progressively decreased (p<0.001) during the 12 weeks. There was no interaction between baseline 25(OH)D levels and changes in trabecular and cortical BMC, vBMD and CSA. Advanced age and higher CTX and P1NP were associated with higher cortical bone loss.

Conclusion: Vitamin D deficiency does not affect the early architectural changes after a DRF. Advanced age and higher bone remodeling were associated with higher cortical bone loss, probably related to immobilization and independent of vitamin D levels.

Keywords: Osteoporosis; Peripheral Quantitative Computed Tomography; Radial Fractures; Vitamin D.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Bone Density / physiology*
  • Bone Remodeling / physiology
  • Conservative Treatment / methods*
  • Female
  • Humans
  • Middle Aged
  • Postmenopause / blood*
  • Prospective Studies
  • Radius Fractures / blood*
  • Radius Fractures / diagnostic imaging*
  • Tomography, X-Ray Computed / methods
  • Vitamin D / blood*
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / diagnostic imaging


  • Vitamin D