Plasma Protein Profile of Carotid Artery Atherosclerosis and Atherosclerotic Outcomes: Meta-Analyses and Mendelian Randomization Analyses

Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1777-1788. doi: 10.1161/ATVBAHA.120.315597. Epub 2021 Mar 4.

Authors

Lars Lind¹, Bruna Gigante², Yan Borné³, Tobias Feldreich⁴, Jerzy Leppert⁵, Pär Hedberg^{5

6}, Carl Johan Östgren^{7

8}, Fredrik H Nyström⁷, Johan Sundström^{1

9}, Johan Ärnlöv⁴, Damiano Baldassarre^{10

11}, Elena Tremoli¹¹, Fabrizio Veglia¹¹, Anders Hamsten², Christopher J O'Donnell^{7

8}, Nora Franceschini¹², Marju Orho-Melander³, Jan Nilsson³, Olle Melander³, Gunnar Engström³, Anders Mälarstig²

Affiliations

¹ Department of Medical Sciences, Uppsala University, Sweden (L.L., J.S.).
² Unit of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Sweden (B.G., A.H., A.M.).
³ Department of Clinical Sciences Malmö, Lund University, Sweden (Y.B., M.O.-M., J.N., O.M., G.E.).
⁴ School of Health and Social Sciences, Dalarna University, Falun, Sweden (T.F., J.A.).
⁵ Centre for Clinical Research, Uppsala University (J.L., P.H.), Västmanland County Hospital, Västerås, Sweden.
⁶ Department of Clinical Physiology (P.H.), Västmanland County Hospital, Västerås, Sweden.
⁷ Department of Health, Medicine and Caring Sciences, Linköping University, Sweden (C.J.O., F.H.N.).
⁸ Department of Medicine, Boston University, MA (C.J.O.).
⁹ The George Institute for Global Health, University of New South Wales, Sydney, Australia (J.S.).
¹⁰ Damiano Baldassarre, Department of Medical Biotechnology and Translational Medicine, Università di Milano (D.B.).
¹¹ Centro Cardiologico Monzino, IRCCS, Milan, Italy (D.B., E.T., F.V.).
¹² Department of Epidemiology, University of North Caroline, Capel Hill (N.F.).

Abstract

[Figure: see text].

Keywords: atherosclerosis; carotid arteries; epidemiology; ischemic stroke; myocardial infarction; protein.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Biomarkers / blood
Blood Proteins / metabolism*
Carotid Artery Diseases / blood*
Carotid Artery Diseases / diagnostic imaging
Carotid Artery Diseases / epidemiology
Carotid Artery Diseases / genetics*
Carotid Intima-Media Thickness
Female
Genetic Variation*
Humans
Incidence
Male
Matrix Metalloproteinase 12 / blood
Mendelian Randomization Analysis
Middle Aged
Plaque, Atherosclerotic
Prognosis
Proteome*
Proteomics
Risk Assessment
Risk Factors
Sweden / epidemiology

Substances

Biomarkers
Blood Proteins
Proteome
MMP12 protein, human
Matrix Metalloproteinase 12

Grants and funding