Management of Sickle Cell Disease Complications Beyond Acute Chest Syndrome

Ugochi O Ogu; Nnenna U Badamosi; Pamela E Camacho; Amado X Freire; Patricia Adams-Graves

doi:10.2147/JBM.S291394

Management of Sickle Cell Disease Complications Beyond Acute Chest Syndrome

J Blood Med. 2021 Feb 25:12:101-114. doi: 10.2147/JBM.S291394. eCollection 2021.

Authors

Ugochi O Ogu¹, Nnenna U Badamosi², Pamela E Camacho³, Amado X Freire⁴, Patricia Adams-Graves¹

Affiliations

¹ Center for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, TN, USA.
² Division of Pediatric Hematology and Oncology, Medical College of Georgia, Augusta, GA, USA.
³ Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
⁴ Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

Abstract

Sickle cell disease results in numerous complications that can lead to significant morbidity and mortality. Amongst them, acute chest syndrome is the leading cause of mortality. As a result, most providers are in tune with this complication and well versed with management. As sickle cell patients now live longer, they face a multitude of other complications that if left unattended, can lead to significant morbidity and mortality as well. It is critical to look beyond acute chest syndrome and adopt a more comprehensive approach to the management of the sickle cell patient.

Keywords: acute chest syndrome; complications; sickle cell disease.

Publication types

Review