Association between Bone Morphogenetic Protein 2 Gene Polymorphisms and Skeletal Fluorosis of The Brick-tea Type Fluorosis in Tibetans and Kazakhs, China

Qun Lou; Ning Guo; Wei Huang; Liaowei Wu; Mengyao Su; Yang Liu; Xiaona Liu; Bingyun Li; Yanmei Yang; Yanhui Gao

doi:10.1080/09603123.2021.1892037

Association between Bone Morphogenetic Protein 2 Gene Polymorphisms and Skeletal Fluorosis of The Brick-tea Type Fluorosis in Tibetans and Kazakhs, China

Int J Environ Health Res. 2022 Jul;32(7):1489-1499. doi: 10.1080/09603123.2021.1892037. Epub 2021 Mar 4.

Authors

Qun Lou^{1

2

3}, Ning Guo^{1

2

3}, Wei Huang^{1

2

3}, Liaowei Wu^{1

2

3}, Mengyao Su^{1

2

3}, Yang Liu^{1

2

3}, Xiaona Liu^{1

2

3}, Bingyun Li^{1

2

3}, Yanmei Yang^{1

2

3}, Yanhui Gao^{1

2

3}

Affiliations

¹ Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
² Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Harbin Medical University, Harbin, China.
³ Heilongjiang Provincial Key Lab of Trace Elements and Human Health Harbin Medical University, Harbin, China.

PMID: 33660557
DOI: 10.1080/09603123.2021.1892037

Abstract

To investigate the potential association between BMP2 single nucleotide polymorphisms (SNPs) and brick-tea-type skeletal fluorosis risk in cross-sectional case-control study conducted in Sinkiang and Qinghai, China, a total of 598 individuals, including 308 Tibetans and 290 Kazakhs, were enrolled. Using the standard WS/192-2008 (China), 221 skeletal fluorosis cases were diagnosed, including 123 Tibetans and 98 Kazakhs. Logistic regressions 2 analysis did not find the association between SNPs (Rs235764, Rs235739 and Rs996544) and skeletal fluorosis. Genetic models, linkage disequilibrium (LD) and haplotype analysis were not found to be associated with risk of skeletal fluorosis after adjustment by age and sex (P>0.05).Our data suggested that Rs 235764, Rs 235739 and Rs 996544 were not linked susceptibility for skeletal fluorosis in our cross-sectional case-control study.

Keywords: Brick-tea type fluorosis; bone morphogenetic proteins-2; single nucleotide polymorphism; skeletal fluorosis.

MeSH terms

Bone Diseases, Metabolic* / chemically induced
Bone Diseases, Metabolic* / genetics
Bone Morphogenetic Protein 2 / genetics*
Case-Control Studies
China / epidemiology
Cross-Sectional Studies
Fluorides / analysis
Fluorides / toxicity
Humans
Polymorphism, Single Nucleotide
Tea / chemistry*
Tibet / epidemiology

Substances

BMP2 protein, human
Bone Morphogenetic Protein 2
Tea
Fluorides