Nuclear Periphery and Telomere Maintenance: TERRA Joins the Stage

Trends Genet. 2021 Jul;37(7):608-611. doi: 10.1016/j.tig.2021.02.003. Epub 2021 Mar 1.


Long noncoding (lnc)RNAs derived from telomeres, the ends of linear eukaryotic chromosomes, help to maintain telomere length and stability by multiple means, including regulation of telomerase activity and recombination-based telomere maintenance. New findings in yeast promote a model in which telomere attachment to the nuclear envelope regulates telomere transcription and maintenance.

Keywords: TERRA; budding yeast; fission yeast; nuclear envelope; telomere; telomeric R-loops.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA-Binding Proteins / genetics
  • Humans
  • Nuclear Envelope / genetics*
  • RNA, Long Noncoding / genetics*
  • Saccharomyces cerevisiae / genetics
  • Telomerase / genetics
  • Telomere / genetics
  • Telomere Homeostasis / genetics*
  • Transcription, Genetic*


  • DNA-Binding Proteins
  • RNA, Long Noncoding
  • Telomerase