Normative dataset for plasma cytokines in healthy human adults

Yingkai Li; John S Yi; Melissa A Russo; Marilyn Rosa-Bray; Kent J Weinhold; Jeffrey T Guptill

doi:10.1016/j.dib.2021.106857

Normative dataset for plasma cytokines in healthy human adults

Data Brief. 2021 Feb 9:35:106857. doi: 10.1016/j.dib.2021.106857. eCollection 2021 Apr.

Authors

Yingkai Li¹, John S Yi², Melissa A Russo¹, Marilyn Rosa-Bray³, Kent J Weinhold², Jeffrey T Guptill^{1

4}

Affiliations

¹ Neuromuscular Division, Department of Neurology, Duke University Medical Center, 915 S. LaSalle St. Ext.; Box 2926, SORF Building; Room 124, Durham, NC 27710, United States.
² Department of Surgery, Duke University School of Medicine, Durham, NC 27710, United States.
³ Biomat USA-Grifols Plasma Operations, United States of America.
⁴ Duke Clinical Research Institute, Durham, NC 27710, United States.

Abstract

We determined normative data for plasma cytokines established from a cohort of 126 carefully screened healthy adults aged 18 to 64 years. Participants were enrolled to ensure an even age and sex distribution and to include at least 30% non-Caucasians. Plasma cytokines for 18 analytes were tested by multiplex immunoassay. The data are presented by age cohort (18-29 years, 30-39, 40-49, and 50-66), as well as by sex and racial background. This dataset complements published normative ranges of cellular subsets generated by comprehensive polychromatic flow cytometry analysis of the healthy human immune system [1]. These data are available to researchers and have value as a reference range for research involving peripheral cytokines.

Keywords: Cytokines; Healthy volunteer; Normative range; Reference range; Reference value.