Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice

Madhulika Sharma; Sireesha Yerrathota; Mackenzie M Thornton; Sumedha Gunewardena

doi:10.1016/j.dib.2021.106873

Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice

Data Brief. 2021 Feb 13:35:106873. doi: 10.1016/j.dib.2021.106873. eCollection 2021 Apr.

Authors

Madhulika Sharma^{1

2}, Sireesha Yerrathota^{1

2}, Mackenzie M Thornton^{1

2}, Sumedha Gunewardena³

Affiliations

¹ Departments of Internal Medicine, United States.
² The Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, KS, United States.
³ Molecular and integrative physiology, United States.

Abstract

The Notch signaling pathway is an important conserved pathway for normal homeostasis during development. However, targeted deletion of Notch4 (Notch4^d1 ) or Notch3 (Notch3^d1 ) in mice is not lethal. In fact, both Notch4^d1 and Notch3^d1 mice develop normally and are fertile. Here we present RNA seq analysis of differential gene expression in the kidneys of Notch4^d1 mice versus the Notch3 ^d1 mice, all on FVB background. Kidneys were collected from Notch4^d1 and Notch3 ^d1 littermates at 3 months of age. RNA sequencing was carried out. The raw data were analyzed for differential gene expression using a negative binomial generalized linear model in the DeSeq2 software package. We used P-value ≤0.05 and an absolute fold change of 1.5 or greater to identify top upregulated and downregulated genes in Notch4 ^d1 mice compared to Notch3 ^d1 mice. The data provided will indentify targets of Notch3 and Notch4 signaling, specifically in kidney diseases where Notch3 or Notch4 are abberantly or redundantly expressed.

Keywords: Chronic kidney disease; HIVAN; Inflammation; Tg26.

Abstract

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