Exercise Training and Revascularization in the Management of Symptomatic Peripheral Artery Disease

Minakshi P Biswas; Warren H Capell; Mary M McDermott; Donald L Jacobs; Joshua A Beckman; Marc P Bonaca; William R Hiatt

doi:10.1016/j.jacbts.2020.08.012

Exercise Training and Revascularization in the Management of Symptomatic Peripheral Artery Disease

JACC Basic Transl Sci. 2021 Feb 22;6(2):174-188. doi: 10.1016/j.jacbts.2020.08.012. eCollection 2021 Feb.

Authors

Minakshi P Biswas^{1

2}, Warren H Capell^{2

3}, Mary M McDermott⁴, Donald L Jacobs⁵, Joshua A Beckman⁶, Marc P Bonaca^{1

2}, William R Hiatt^{1

2}

Affiliations

¹ Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
² CPC Clinical Research, Aurora, Colorado, USA.
³ Division of Endocrinology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
⁴ Division of General Internal Medicine and Geriatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
⁵ Division of Vascular Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
⁶ Division of Cardiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.

Abstract

Exercise therapy and lower extremity revascularization both improve walking performance in symptomatic patients with peripheral artery disease. The combination of therapies provides greater benefit than either alone and may reduce the need for subsequent revascularization procedures, but further trials with longer follow-up are needed for the outcome of subsequent revascularization.

Keywords: 6MW, 6-minute walk; CMS, Centers for Medicare and Medicaid Services; ET, exercise therapy; HBE, home-based exercise; LER, lower extremity revascularization; MCID, minimum clinically important difference; PAD, peripheral artery disease; PRO, patient-reported outcome; PWD, peak walking distance; PWT, peak walking time; SET, supervised exercise training; SF-36, Medical Outcomes Short Form–36; VascuQOL, Vascular Quality of Life; WIQ, Walking Impairment Questionnaire; evidence; exercise therapy (supervised exercise training, home-based exercise programs); lower extremity revascularization.

Publication types

Review