A Niche Above: A Novel Modality of Stem Cell Regulation in Mammalian Skin Epidermis

Cell Stem Cell. 2021 Mar 4;28(3):365-366. doi: 10.1016/j.stem.2021.02.012.


In this issue of Cell Stem Cell, Ning et al. (2021) demonstrate that contractility in differentiating, suprabasally located keratinocytes acts non-cell-autonomously to regulate the replication and differentiation of the stem/progenitor keratinocytes in the basal layer of epidermis. This finding expands our understanding of the niche that regulates stem/progenitor cells in skin.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation
  • Epidermal Cells
  • Epidermis
  • Epigenomics*
  • Keratinocytes
  • Stem Cells
  • Transcription Factors*


  • Transcription Factors