A Niche Above: A Novel Modality of Stem Cell Regulation in Mammalian Skin Epidermis

Pierre A Coulombe; Sara A Wickström

doi:10.1016/j.stem.2021.02.012

A Niche Above: A Novel Modality of Stem Cell Regulation in Mammalian Skin Epidermis

Cell Stem Cell. 2021 Mar 4;28(3):365-366. doi: 10.1016/j.stem.2021.02.012.

Authors

Pierre A Coulombe¹, Sara A Wickström²

Affiliations

¹ Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: coulombe@umich.edu.
² Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Finland; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, Finland.

Abstract

In this issue of Cell Stem Cell, Ning et al. (2021) demonstrate that contractility in differentiating, suprabasally located keratinocytes acts non-cell-autonomously to regulate the replication and differentiation of the stem/progenitor keratinocytes in the basal layer of epidermis. This finding expands our understanding of the niche that regulates stem/progenitor cells in skin.

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MeSH terms

Animals
Cell Differentiation
Epidermal Cells
Epidermis
Epigenomics*
Keratinocytes
Stem Cells
Transcription Factors*

Substances

Transcription Factors

Abstract

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MeSH terms

Substances

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